A Biomimetically Inspired Synthesis of the Dehydropiperidine Domain of Thiostrepton We thank Drs. D. H. Huang and L. Pasternack, G. Suizdak, and R. Chadja for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), fellowships from The Academy of Finland (M.N.), The Skaggs Institute for Research (M.Z.), and Bayer AG (S.B.), and grants from Abbott, Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

K. C. Nicolaou; Marta Nevalainen; Brian S. Safina; Mark Zak; Stephan Bulat

doi:10.1002/1521-3773(20020603)41:11<1941::aid-anie1941>3.0.co;2-v

A Biomimetically Inspired Synthesis of the Dehydropiperidine Domain of Thiostrepton We thank Drs. D. H. Huang and L. Pasternack, G. Suizdak, and R. Chadja for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), fellowships from The Academy of Finland (M.N.), The Skaggs Institute for Research (M.Z.), and Bayer AG (S.B.), and grants from Abbott, Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

Angewandte Chemie International Edition ◽

10.1002/1521-3773(20020603)41:11<1941::aid-anie1941>3.0.co;2-v ◽

2002 ◽

Vol 41 (11) ◽

pp. 1941 ◽

Cited By ~ 57

Author(s):

K. C. Nicolaou ◽

Marta Nevalainen ◽

Brian S. Safina ◽

Mark Zak ◽

Stephan Bulat

Keyword(s):

Financial Support ◽

Chemical Biology ◽

Mass Spectrometric ◽

National Institutes Of Health ◽

X Ray

Download Full-text

A Biomimetically Inspired Synthesis of the Dehydropiperidine Domain of Thiostrepton We thank Drs. D. H. Huang and L. Pasternack, G. Suizdak, and R. Chadja for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), fellowships from The Academy of Finland (M.N.), The Skaggs Institute for Research (M.Z.), and Bayer AG (S.B.), and grants from Abbott, Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

Angewandte Chemie ◽

10.1002/1521-3757(20020603)114:11<2021::aid-ange2021>3.0.co;2-j ◽

2002 ◽

Vol 114 (11) ◽

pp. 2021 ◽

Cited By ~ 26

Author(s):

K. C. Nicolaou ◽

Marta Nevalainen ◽

Brian S. Safina ◽

Mark Zak ◽

Stephan Bulat

Keyword(s):

Financial Support ◽

Chemical Biology ◽

Mass Spectrometric ◽

National Institutes Of Health ◽

X Ray

Download Full-text

Stereocontrolled Synthesis of the Quinaldic Acid Macrocyclic System of Thiostrepton We thank Drs. D. H. Huang and G. Suizdak for NMR spectroscopic and mass spectrometric assistance, respectively, as well as Mike Sertic (University of California, San Diego) for experimental assistance. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), fellowships from The Skaggs Institute for Research (to M.Z. and F.Z.), and grants from Abbott, Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

Angewandte Chemie International Edition ◽

10.1002/1521-3773(20020603)41:11<1937::aid-anie1937>3.0.co;2-y ◽

2002 ◽

Vol 41 (11) ◽

pp. 1937 ◽

Cited By ~ 19

Author(s):

K. C. Nicolaou ◽

Brian S. Safina ◽

Christian Funke ◽

Mark Zak ◽

Frédéric J. Zécri

Keyword(s):

Financial Support ◽

San Diego ◽

Chemical Biology ◽

Mass Spectrometric ◽

National Institutes Of Health ◽

University Of California ◽

Quinaldic Acid ◽

Stereocontrolled Synthesis ◽

Macrocyclic System

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HIO3 and I2O5: Mild and Selective Alternative Reagents to IBX for the Dehydrogenation of Aldehydes and Ketones We thank Dr. D. H. Huang, Dr. G. Suizdak, and Dr. Raj Chahda for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, fellowships from GlaxoWellcome (T.M.) and the National Science Foundation (P.S.B.), and grants from Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

Angewandte Chemie ◽

10.1002/1521-3757(20020415)114:8<1444::aid-ange1444>3.0.co;2-t ◽

2002 ◽

Vol 114 (8) ◽

pp. 1444 ◽

Cited By ~ 23

Author(s):

K. C. Nicolaou ◽

Tamsyn Montagnon ◽

Phil S. Baran

Keyword(s):

Financial Support ◽

National Science Foundation ◽

Chemical Biology ◽

Mass Spectrometric ◽

X Ray ◽

National Science ◽

Aldehydes And Ketones

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A Novel Regio- and Stereoselective Synthesis of Sulfamidates from 1,2-Diols Using Burgess and Related Reagents: A Facile Entry into β-Amino Alcohols We thank Professor K. Barry Sharpless for the gracious donation of several of the starting diol substrates. We also thank Drs. D. H. Huang, G. Suizdak, and R. Chadja for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, predoctoral fellowships from the National Science Foundation and Pfizer (S.A.S.), a postdoctoral fellowship from The Skaggs Institute for Chemical Biology (X.H.), and grants from American Biosciences, Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffman-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

Angewandte Chemie International Edition ◽

10.1002/1521-3773(20020301)41:5<834::aid-anie834>3.0.co;2-v ◽

2002 ◽

Vol 41 (5) ◽

pp. 834 ◽

Cited By ~ 60

Author(s):

K. C. Nicolaou ◽

Xianhai Huang ◽

Scott A. Snyder ◽

Paraselli Bheema Rao ◽

Marco Bella ◽

...

Keyword(s):

Financial Support ◽

National Science Foundation ◽

Chemical Biology ◽

Stereoselective Synthesis ◽

Amino Alcohols ◽

Mass Spectrometric ◽

X Ray ◽

National Science ◽

Postdoctoral Fellowship

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Stereocontrolled Synthesis of the Quinaldic Acid Macrocyclic System of Thiostrepton We thank Drs. D. H. Huang and G. Suizdak for NMR spectroscopic and mass spectrometric assistance, respectively, as well as Mike Sertic (University of California, San Diego) for experimental assistance. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), fellowships from The Skaggs Institute for Research (to M.Z. and F.Z.), and grants from Abbott, Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

Angewandte Chemie ◽

10.1002/1521-3757(20020603)114:11<2017::aid-ange2017>3.0.co;2-m ◽

2002 ◽

Vol 114 (11) ◽

pp. 2017 ◽

Cited By ~ 9

Author(s):

K. C. Nicolaou ◽

Brian S. Safina ◽

Christian Funke ◽

Mark Zak ◽

Frédéric J. Zécri

Keyword(s):

Financial Support ◽

San Diego ◽

Chemical Biology ◽

Mass Spectrometric ◽

National Institutes Of Health ◽

University Of California ◽

Quinaldic Acid ◽

Stereocontrolled Synthesis ◽

Macrocyclic System

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Synthesis of the ABCD Ring System of Azaspiracid We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a predoctoral fellowship from Bristol-Myers Squibb (to F.B.), postdoctoral fellowships from The Skaggs Institute for Research (to W.Q.), the Academy of Finland, the Ella and Georg Ehrnrooth Foundation and the Tauno Tönning Foundation (all to P.M.P.), and Bayer AG (to J.H.), as well as grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

Angewandte Chemie International Edition ◽

10.1002/1521-3773(20011105)40:21<4068::aid-anie4068>3.0.co;2-y ◽

2001 ◽

Vol 40 (21) ◽

pp. 4068 ◽

Cited By ~ 37

Author(s):

K. C. Nicolaou ◽

Wenyuan Qian ◽

Federico Bernal ◽

Noriaki Uesaka ◽

Petri M. Pihko ◽

...

Keyword(s):

Chemical Biology ◽

Ring System ◽

Mass Spectrometric ◽

National Institutes Of Health

Download Full-text

A Click Chemistry Approach to Tetrazoles by Huisgen 1,3-Dipolar Cycloaddition: Synthesis of 5-Acyltetrazoles from Azides and Acyl Cyanides We thank the National Institute of General Medical Sciences, National Institutes of Health (GM-28384), the National Science Foundation (CHE-9985553), the Skaggs Institute for Chemical Biology for a Predoctoral Fellowship (Z.D.), and the W. M. Keck Foundation for financial support.

Angewandte Chemie ◽

10.1002/1521-3757(20020617)114:12<2217::aid-ange2217>3.0.co;2-x ◽

2002 ◽

Vol 114 (12) ◽

pp. 2217 ◽

Cited By ~ 34

Author(s):

Zachary P. Demko ◽

K. Barry Sharpless

Keyword(s):

Click Chemistry ◽

Financial Support ◽

National Science Foundation ◽

Chemical Biology ◽

National Institutes Of Health ◽

Dipolar Cycloaddition ◽

Medical Sciences ◽

National Science

Download Full-text

A Click Chemistry Approach to Tetrazoles by Huisgen 1,3-Dipolar Cycloaddition: Synthesis of 5-Acyltetrazoles from Azides and Acyl Cyanides We thank the National Institute of General Medical Sciences, National Institutes of Health (GM-28384), the National Science Foundation (CHE-9985553), the Skaggs Institute for Chemical Biology for a Predoctoral Fellowship (Z.D.), and the W. M. Keck Foundation for financial support.

Angewandte Chemie International Edition ◽

10.1002/1521-3773(20020617)41:12<2113::aid-anie2113>3.0.co;2-q ◽

2002 ◽

Vol 41 (12) ◽

pp. 2113 ◽

Cited By ~ 202

Author(s):

Zachary P. Demko ◽

K. Barry Sharpless

Keyword(s):

Click Chemistry ◽

Financial Support ◽

National Science Foundation ◽

Chemical Biology ◽

National Institutes Of Health ◽

Dipolar Cycloaddition ◽

Medical Sciences ◽

National Science

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Model Studies Towards Azadirachtin: Part 1. Construction of the Crowded C8bC14 Bond by Radical Chemistry We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, postdoctoral fellowships from Bayer AG (to M.F.) and the G. E. Hewitt Foundation (to K.W.H.), a predoctoral fellowship from the Division of Organic Chemistry of the American Chemical Society sponsored by Novartis (to A.J.R.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough.

Angewandte Chemie ◽

10.1002/1521-3757(20020617)114:12<2207::aid-ange2207>3.0.co;2-z ◽

2002 ◽

Vol 114 (12) ◽

pp. 2207 ◽

Cited By ~ 16

Author(s):

K. C. Nicolaou ◽

Markus Follmann ◽

A. J. Roecker ◽

Kevin W. Hunt

Keyword(s):

Organic Chemistry ◽

Chemical Biology ◽

American Chemical Society ◽

Chemical Society ◽

Mass Spectrometric ◽

National Institutes Of Health ◽

Radical Chemistry ◽

Model Studies

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Model Studies Towards Azadirachtin: Part 2. Construction of the Crowded C8bC14 Bond by Transition Metal Chemistry We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, a predoctoral fellowship from the Division of Organic Chemistry of the American Chemical Society sponsored by Novartis (to A.J.R.), postdoctoral fellowships from Bayer AG (to M.F.), and Association pour la Recherche sur le Cancer (to R.B.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough.

Angewandte Chemie ◽

10.1002/1521-3757(20020617)114:12<2211::aid-ange2211>3.0.co;2-w ◽

2002 ◽

Vol 114 (12) ◽

pp. 2211 ◽

Cited By ~ 19

Author(s):

K. C. Nicolaou ◽

A. J. Roecker ◽

Markus Follmann ◽

Rachid Baati

Keyword(s):

Organic Chemistry ◽

Transition Metal ◽

Chemical Biology ◽

American Chemical Society ◽

Chemical Society ◽

Mass Spectrometric ◽

National Institutes Of Health ◽

Transition Metal Chemistry ◽

Metal Chemistry ◽

Model Studies

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